SCOPe 2.06: Domain d3w2oa1: 3w2o A:698-1017

Lineage for d3w2oa1 (3w2o A:698-1017)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (90 PDB entries)
   Uniprot P00533 702-1018

8. Domain d3w2oa1: 3w2o A:698-1017 [194105]
   Other proteins in same PDB: d3w2oa2
   automated match to d1m14a_
   complexed with 03p; mutant

Details for d3w2oa1

PDB Entry: 3w2o, 2.35 Å

PDB Description: egfr kinase domain t790m/l858r mutant with tak-285

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d3w2oa1:

Sequence, based on SEQRES records:

>d3w2oa1 d.144.1.7 (A:698-1017) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvp
ikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqpp
ictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnf
yralmdeedmddvvdadeyl

Sequence, based on observed residues (ATOM records):

>d3w2oa1 d.144.1.7 (A:698-1017) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
apnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkank
eildeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnw
cvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyhaeggkvp
ikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqpp
ictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpmddvvda
deyl

Timeline for d3w2oa1:

• d3w2oa1 first appeared in SCOPe 2.02, called d3w2oa_
  
• d3w2oa1 was called d3w2oa_ in SCOPe 2.05
  
• d3w2oa1 appears in SCOPe 2.07
  
• d3w2oa1 appears in the current release, SCOPe 2.08