Lineage for d4i24a_ (4i24 A:)

  1. Root: SCOPe 2.02
  2. 1190016Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1220003Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 1220004Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 1220070Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 1221476Protein automated matches [190091] (10 species)
    not a true protein
  7. 1221539Species Homo sapiens [TaxId:9606] [192729] (55 PDB entries)
  8. 1221549Domain d4i24a_: 4i24 A: [193289]
    automated match to d1m14a_
    complexed with 1c9

Details for d4i24a_

PDB Entry: 4i24 (more details), 1.8 Å

PDB Description: Structure of T790M EGFR kinase domain co-crystallized with dacomitinib
PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d4i24a_:

Sequence, based on SEQRES records: (download)

>d4i24a_ d.144.1.7 (A:) automated matches {Homo sapiens [TaxId: 9606]}
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkankei
ldeayvmasvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcv
qiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkvpik
wmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppic
tidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyr
almdeedmddvvdad

Sequence, based on observed residues (ATOM records): (download)

>d4i24a_ d.144.1.7 (A:) automated matches {Homo sapiens [TaxId: 9606]}
nqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelankeildeayvm
asvdnphvcrllgicltstvqlimqlmpfgclldyvrehkdnigsqyllnwcvqiakgmn
yledrrlvhrdlaarnvlvktpqhvkitdfglakllvpikwmalesilhriythqsdvws
ygvtvwelmtfgskpydgipaseissilekgerlpqppictidvymimvkcwmidadsrp
kfreliiefskmardpqrylviqgdermhlpsptdsnfyralmdeedmddvvdad

SCOPe Domain Coordinates for d4i24a_:

Click to download the PDB-style file with coordinates for d4i24a_.
(The format of our PDB-style files is described here.)

Timeline for d4i24a_: