SCOPe 2.08: Domain d3rlqa1: 3rlq A:9-225

Lineage for d3rlqa1 (3rlq A:9-225)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (2 proteins)

6. Protein HSP90 [55876] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [55878] (189 PDB entries)
   Uniprot P08238 10-220 # HSP 90-beta isoform ! Uniprot P07900 16-223

8. Domain d3rlqa1: 3rlq A:9-225 [185026]
   Other proteins in same PDB: d3rlqa2, d3rlqb2
   automated match to d1osfa_
   complexed with 3rq, po4

Details for d3rlqa1

PDB Entry: 3rlq, 1.9 Å

PDB Description: co-crystal structure of the hsp90 atp binding domain in complex with 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7h-pyrrolo[2,3- d]pyrimidine-5- carbonitrile

PDB Compounds: (A:) Heat shock protein HSP 90-alpha

SCOPe Domain Sequences for d3rlqa1:

Sequence; same for both SEQRES and ATOM records:

>d3rlqa1 d.122.1.1 (A:9-225) HSP90 {Human (Homo sapiens) [TaxId: 9606]}
dqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdps
kldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadi
smigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvil
hlkedqteyleerrikeivkkhsqfigypitlfveke

Timeline for d3rlqa1:

• d3rlqa1 first appeared in SCOPe 2.01, called d3rlqa_
  
• d3rlqa1 appears in SCOPe 2.07