SCOPe 2.05: Domain d3lfsa_: 3lfs A:

Lineage for d3lfsa_ (3lfs A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Cyclin-dependent PK, CDK2 [88855] (2 species)
   CMGC group; CDKs subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [88856] (348 PDB entries)
   Uniprot P24941

8. Domain d3lfsa_: 3lfs A: [180262]
   automated match to d1aq1a_
   complexed with a07

Details for d3lfsa_

PDB Entry: 3lfs, 2.4 Å

PDB Description: Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor

PDB Compounds: (A:) Cell division protein kinase 2

SCOPe Domain Sequences for d3lfsa_:

Sequence, based on SEQRES records:

>d3lfsa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Sequence, based on observed residues (ATOM records):

>d3lfsa_ d.144.1.7 (A:) Cyclin-dependent PK, CDK2 {Human (Homo sapiens) [TaxId: 9606]}
menfqkvekigegtygvvykarnkltgevvalkkirpstaireisllkelnhpnivklld
vihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdl
kpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyystavdiws
lgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdf
skvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

Timeline for d3lfsa_:

• d3lfsa_ first appeared in SCOPe 2.01
  
• d3lfsa_ appears in SCOPe 2.04
  
• d3lfsa_ appears in SCOPe 2.06
  
• d3lfsa_ appears in the current release, SCOPe 2.08