SCOPe 2.02: Domain d3fupb_: 3fup B:

Lineage for d3fupb_ (3fup B:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.0: automated matches [191359] (1 protein)
   not a true family

6. Protein automated matches [190417] (7 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187294] (54 PDB entries)

8. Domain d3fupb_: 3fup B: [176065]
   automated match to d1u46a_
   complexed with mi1

Details for d3fupb_

PDB Entry: 3fup, 2.4 Å

PDB Description: crystal structures of jak1 and jak2 inhibitor complexes

PDB Compounds: (B:) Tyrosine-protein kinase JAK2

SCOPe Domain Sequences for d3fupb_:

Sequence, based on SEQRES records:

>d3fupb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqytsq
ickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespif
wyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhli
ellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

Sequence, based on observed residues (ATOM records):

>d3fupb_ d.144.1.0 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdferei
eilkslqhdnivkykgvcysnlklimeylpygslrdylqkhkeridhikllqytsqickg
meylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyap
eslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellk
nngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdqmag

Timeline for d3fupb_:

• d3fupb_ first appeared in SCOPe 2.01
  
• d3fupb_ appears in SCOPe 2.03
  
• d3fupb_ appears in the current release, SCOPe 2.08