SCOPe 2.04: Domain d3fs6a_: 3fs6 A:

Lineage for d3fs6a_ (3fs6 A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (61 PDB entries)

8. Domain d3fs6a_: 3fs6 A: [176013]
   automated match to d1dlra_
   complexed with dh1, ndp; mutant

Details for d3fs6a_

PDB Entry: 3fs6, 1.23 Å

PDB Description: Correlations of Inhibitor Kinetics for Pneumocystis jirovecii and Human Dihydrofolate Reductase with Structural Data for Human Active Site Mutant Enzyme Complexes

PDB Compounds: (A:) dihydrofolate reductase

SCOPe Domain Sequences for d3fs6a_:

Sequence; same for both SEQRES and ATOM records:

>d3fs6a_ c.71.1.1 (A:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d3fs6a_:

• d3fs6a_ first appeared in SCOPe 2.01
  
• d3fs6a_ appears in SCOPe 2.03
  
• d3fs6a_ appears in SCOPe 2.05
  
• d3fs6a_ appears in the current release, SCOPe 2.08