SCOPe 2.05: Domain d3e50d_: 3e50 D:

Lineage for d3e50d_ (3e50 D:)

1. Root: SCOPe 2.05

2. Class g: Small proteins [56992] (92 folds)

3. Fold g.3: Knottins (small inhibitors, toxins, lectins) [57015] (19 superfamilies)
   disulfide-bound fold; contains beta-hairpin with two adjacent disulfides

4. Superfamily g.3.11: EGF/Laminin [57196] (8 families)

5. Family g.3.11.1: EGF-type module [57197] (23 proteins)

6. Protein Transforming growth factor alpha [57217] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [57218] (7 PDB entries)

8. Domain d3e50d_: 3e50 D: [174666]
   Other proteins in same PDB: d3e50c_
   automated match to d1yufa_
   complexed with zn

Details for d3e50d_

PDB Entry: 3e50, 2.3 Å

PDB Description: crystal structure of human insulin degrading enzyme in complex with transforming growth factor-alpha

PDB Compounds: (D:) Protransforming growth factor alpha

SCOPe Domain Sequences for d3e50d_:

Sequence, based on SEQRES records:

>d3e50d_ g.3.11.1 (D:) Transforming growth factor alpha {Human (Homo sapiens) [TaxId: 9606]}
vvshfndcpdshtq

Sequence, based on observed residues (ATOM records):

>d3e50d_ g.3.11.1 (D:) Transforming growth factor alpha {Human (Homo sapiens) [TaxId: 9606]}
vvshfdshtq

Timeline for d3e50d_:

• d3e50d_ first appeared in SCOPe 2.01
  
• d3e50d_ appears in SCOPe 2.04
  
• d3e50d_ appears in SCOPe 2.06
  
• d3e50d_ appears in the current release, SCOPe 2.08