Lineage for d3d08a_ (3d08 A:)

  1. Root: SCOPe 2.03
  2. 1287432Class b: All beta proteins [48724] (174 folds)
  3. 1300526Fold b.2: Common fold of diphtheria toxin/transcription factors/cytochrome f [49379] (10 superfamilies)
    sandwich; 9 strands in 2 sheet; greek-key; subclass of immunoglobin-like fold
  4. 1300967Superfamily b.2.5: p53-like transcription factors [49417] (7 families) (S)
  5. 1300968Family b.2.5.2: p53 DNA-binding domain-like [81314] (3 proteins)
  6. 1300969Protein p53 tumor suppressor, DNA-binding domain [49419] (2 species)
  7. 1300970Species Human (Homo sapiens) [TaxId:9606] [49420] (32 PDB entries)
  8. 1300975Domain d3d08a_: 3d08 A: [173592]
    automated match to d1gzha_
    complexed with zn; mutant

Details for d3d08a_

PDB Entry: 3d08 (more details), 1.4 Å

PDB Description: human p53 core domain with hot spot mutation r249s and second-site suppressor mutation h168r
PDB Compounds: (A:) Cellular tumor antigen p53

SCOPe Domain Sequences for d3d08a_:

Sequence, based on SEQRES records: (download)

>d3d08a_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
vpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppgtr
vramaiykqsqrmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrhsv
vvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvca
cpgrdrrteee

Sequence, based on observed residues (ATOM records): (download)

>d3d08a_ b.2.5.2 (A:) p53 tumor suppressor, DNA-binding domain {Human (Homo sapiens) [TaxId: 9606]}
vpsqktyqgsygfrlgflhsvtctyspalnkmfcqlaktcpvqlwvdstpppgtrvrama
iykqsqrmtevvrrcphhercglappqhlirvegnlrveylddrntfrhsvvvpyeppev
gsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvcacpgrdrrte
ee

SCOPe Domain Coordinates for d3d08a_:

Click to download the PDB-style file with coordinates for d3d08a_.
(The format of our PDB-style files is described here.)

Timeline for d3d08a_: