SCOPe 2.03: Domain d3cu8b_: 3cu8 B:

Lineage for d3cu8b_ (3cu8 B:)

1. Root: SCOPe 2.03

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.118: alpha-alpha superhelix [48370] (24 superfamilies)
   multihelical; 2 (curved) layers: alpha/alpha; right-handed superhelix

4. Superfamily a.118.7: 14-3-3 protein [48445] (1 family)
   automatically mapped to Pfam PF00244

5. Family a.118.7.1: 14-3-3 protein [48446] (5 proteins)

6. Protein zeta isoform [48449] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48451] (7 PDB entries)

8. Domain d3cu8b_: 3cu8 B: [173465]
   automated match to d1qjba_
   complexed with mg, ppi

Details for d3cu8b_

PDB Entry: 3cu8, 2.4 Å

PDB Description: impaired binding of 14-3-3 to raf1 is linked to noonan and leopard syndrome

PDB Compounds: (B:) 14-3-3 protein zeta/delta

SCOPe Domain Sequences for d3cu8b_:

Sequence, based on SEQRES records:

>d3cu8b_ a.118.7.1 (B:) zeta isoform {Human (Homo sapiens) [TaxId: 9606]}
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqktegaekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylk
mkgdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyye
ilnspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

Sequence, based on observed residues (ATOM records):

>d3cu8b_ a.118.7.1 (B:) zeta isoform {Human (Homo sapiens) [TaxId: 9606]}
mdknelvqkaklaeqaeryddmaacmksvteqgaelsneernllsvayknvvgarrsswr
vvssieqkteekkqqmareyrekietelrdicndvlsllekflipnasqaeskvfylkmk
gdyyrylaevaagddkkgivdqsqqayqeafeiskkemqpthpirlglalnfsvfyyeil
nspekacslaktafdeaiaeldtlseesykdstlimqllrdnltlwts

Timeline for d3cu8b_:

• d3cu8b_ first appeared in SCOPe 2.01
  
• d3cu8b_ appears in SCOPe 2.02
  
• d3cu8b_ appears in SCOPe 2.04
  
• d3cu8b_ appears in the current release, SCOPe 2.08