SCOPe 2.02: Domain d3hhra_: 3hhr A:

Lineage for d3hhra_ (3hhr A:)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)

6. Protein Growth hormone, somatotropin [47276] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47277] (9 PDB entries)

8. Domain d3hhra_: 3hhr A: [16835]
   Other proteins in same PDB: d3hhrb1, d3hhrb2, d3hhrc1, d3hhrc2

Details for d3hhra_

PDB Entry: 3hhr, 2.8 Å

PDB Description: human growth hormone and extracellular domain of its receptor: crystal structure of the complex

PDB Compounds: (A:) human growth hormone

SCOPe Domain Sequences for d3hhra_:

Sequence, based on SEQRES records:

>d3hhra_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleeg
iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
qcrsvegscg

Sequence, based on observed residues (ATOM records):

>d3hhra_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleeg
iqtlmgrledgsprtgqifkqtyskfdtdallknygllycfrkdmdkvetflrivqcrsv
egscg

Timeline for d3hhra_:

• d3hhra_ first appeared (with stable ids) in SCOP 1.55
  
• d3hhra_ appears in SCOPe 2.01
  
• d3hhra_ appears in SCOPe 2.03
  
• d3hhra_ appears in the current release, SCOPe 2.08