SCOPe 2.07: Domain d1hwga_: 1hwg A:

Lineage for d1hwga_ (1hwg A:)

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.26: 4-helical cytokines [47265] (1 superfamily)
   core: 4 helices; bundle, closed; left-handed twist; 2 crossover connections

4. Superfamily a.26.1: 4-helical cytokines [47266] (4 families)
   there are two different topoisomers of this fold with different entanglements of the two crossover connections

5. Family a.26.1.1: Long-chain cytokines [47267] (10 proteins)

6. Protein Growth hormone, somatotropin [47276] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [47277] (9 PDB entries)

8. Domain d1hwga_: 1hwg A: [16834]
   Other proteins in same PDB: d1hwgb1, d1hwgb2, d1hwgc1, d1hwgc2

Details for d1hwga_

PDB Entry: 1hwg, 2.5 Å

PDB Description: 1:2 complex of human growth hormone with its soluble binding protein

PDB Compounds: (A:) growth hormone

SCOPe Domain Sequences for d1hwga_:

Sequence, based on SEQRES records:

>d1hwga_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleeg
iqtlmgrledgsprtgqifkqtyskfdtnshnddallknygllycfrkdmdkvetflriv
qcrsvegscg

Sequence, based on observed residues (ATOM records):

>d1hwga_ a.26.1.1 (A:) Growth hormone, somatotropin {Human (Homo sapiens) [TaxId: 9606]}
fptiplsrlfdnamlrahrlhqlafdtyqefeeayipkeqkysflqnpqtslcfsesipt
psnreetqqksnlellrisllliqswlepvqflrsvfanslvygasdsnvydllkdleeg
iqtlmgrledgsprtgqifkqtyskfddallknygllycfrkdmdkvetflrivqcrsve
gscg

Timeline for d1hwga_:

• d1hwga_ first appeared (with stable ids) in SCOP 1.55
  
• d1hwga_ appears in SCOPe 2.06
  
• d1hwga_ appears in the current release, SCOPe 2.08