SCOPe 2.04: Domain d2pqka_: 2pqk A:

Lineage for d2pqka_ (2pqk A:)

1. Root: SCOPe 2.04

2. Class f: Membrane and cell surface proteins and peptides [56835] (57 folds)

3. Fold f.1: Toxins' membrane translocation domains [56836] (5 superfamilies)
   multi-helical domains of various folds which is thought to unfold in the membrane

4. Superfamily f.1.4: Bcl-2 inhibitors of programmed cell death [56854] (2 families)
   PROVISIONAL CLASSIFICATION, based on structural similarity to the diphtheria toxin domain

5. Family f.1.4.1: Bcl-2 inhibitors of programmed cell death [56855] (11 proteins)
   Pfam PF00452

6. Protein EAT/MCL-1 (Myeloid cell leukemia sequence 1) [118212] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [188549] (1 PDB entry)

8. Domain d2pqka_: 2pqk A: [167245]
   automated match to d1wsxa_
   complexed with na, zn

Details for d2pqka_

PDB Entry: 2pqk, 2 Å

PDB Description: x-ray crystal structure of human mcl-1 in complex with bim bh3

PDB Compounds: (A:) Induced myeloid leukemia cell differentiation protein Mcl-1

SCOPe Domain Sequences for d2pqka_:

Sequence, based on SEQRES records:

>d2pqka_ f.1.4.1 (A:) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkpmgrsgatsrkaletlrrvgdgvqrnhetafqgm
lrkldikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqesciepla
esitdvlvrtkrdwlvkqrgwdgfveffhv

Sequence, based on observed residues (ATOM records):

>d2pqka_ f.1.4.1 (A:) EAT/MCL-1 (Myeloid cell leukemia sequence 1) {Human (Homo sapiens) [TaxId: 9606]}
delyrqsleiisrylreqatgakdtkgatsrkaletlrrvgdgvqrnhetafqgmlrkld
ikneddvkslsrvmihvfsdgvtnwgrivtlisfgafvakhlktinqescieplaesitd
vlvrtkrdwlvkqrgwdgfveffhv

Timeline for d2pqka_:

• d2pqka_ first appeared in SCOPe 2.01
  
• d2pqka_ appears in SCOPe 2.03
  
• d2pqka_ appears in SCOPe 2.05
  
• d2pqka_ appears in the current release, SCOPe 2.08