SCOPe 2.02: Domain d3bjca1: 3bjc A:535-860

Lineage for d3bjca1 (3bjc A:535-860)

1. Root: SCOPe 2.02

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (17 PDB entries)
   Uniprot O76074 534-860

8. Domain d3bjca1: 3bjc A:535-860 [155329]
   automatically matched to d1t9ra_
   complexed with mg, wan, zn

Details for d3bjca1

PDB Entry: 3bjc, 2 Å

PDB Description: Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d3bjca1:

Sequence, based on SEQRES records:

>d3bjca1 a.211.1.2 (A:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d3bjca1 a.211.1.2 (A:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrekknkipsmqvgfidaiclqlyealthvsedcfplldgcrkn
rqkwqalaeqq

Timeline for d3bjca1:

• d3bjca1 first appeared in SCOP 1.75
  
• d3bjca1 appears in SCOPe 2.01
  
• d3bjca1 appears in SCOPe 2.03
  
• d3bjca1 appears in the current release, SCOPe 2.08, called d3bjca_