SCOPe 2.07: Domain d2r7ba_: 2r7b A:

Lineage for d2r7ba_ (2r7b A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein 3-phosphoinositide dependent protein kinase-1 Pdk1 [90036] (1 species)
   AGC group; PBK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [90037] (25 PDB entries)
   Uniprot O15530 75-363

8. Domain d2r7ba_: 2r7b A: [151626]
   automated match to d4eopc_
   complexed with 253, pse, so4

Details for d2r7ba_

PDB Entry: 2r7b, 2.7 Å

PDB Description: Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a dibenzonaphthyridine inhibitor

PDB Compounds: (A:) Phosphoinositide-dependent protein kinase 1

SCOPe Domain Sequences for d2r7ba_:

Sequence, based on SEQRES records:

>d2r7ba_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspell
teksackssdlwalgciiyqlvaglppfragneylifqkiikleydfpekffpkardlve
kllvldatkrlgceemegygplkahpffesvtwenlhqqtppklt

Sequence, based on observed residues (ATOM records):

>d2r7ba_ d.144.1.7 (A:) 3-phosphoinositide dependent protein kinase-1 Pdk1 {Human (Homo sapiens) [TaxId: 9606]}
rkkrpedfkfgkilgegsfstvvlarelatsreyaikilekrhiikenkvpyvtrerdvm
srldhpffvklyftfqddeklyfglsyakngellkyirkigsfdetctrfytaeivsale
ylhgkgiihrdlkpenillnedmhiqitdfgtakvlfvgtaqyvspellteksackssdl
walgciiyqlvaglppfragneylifqkiikleydfpekffpkardlvekllvldatkrl
gceemegygplkahpffesvtwenlhqqtppklt

Timeline for d2r7ba_:

• d2r7ba_ first appeared in SCOP 1.75, called d2r7ba1
  
• d2r7ba_ appears in SCOPe 2.06
  
• d2r7ba_ appears in the current release, SCOPe 2.08