SCOPe 2.05: Domain d2p4yb_: 2p4y B:

Lineage for d2p4yb_ (2p4y B:)

1. Root: SCOPe 2.05

2. Class a: All alpha proteins [46456] (286 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Peroxisome proliferator activated receptor gamma, PPAR-gamma [48524] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [48525] (94 PDB entries)
   Uniprot P37231 232-505

8. Domain d2p4yb_: 2p4y B: [149222]
   automated match to d1wm0x_
   complexed with c03, trs

Details for d2p4yb_

PDB Entry: 2p4y, 2.25 Å

PDB Description: Crystal structure of human PPAR-gamma-ligand binding domain complexed with an indole-based modulator

PDB Compounds: (B:) Peroxisome proliferator-activated receptor gamma

SCOPe Domain Sequences for d2p4yb_:

Sequence, based on SEQRES records:

>d2p4yb_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
adlralakhlydsyiksfpltkakarailtgkttdkspfviydmnslmmgedkikfkhit
plqeqskevairifqgcqfrsveavqeiteyaksipgfvnldlndqvtllkygvheiiyt
mlaslmnkdgvlisegqgfmtreflkslrkpfgdfmepkfefavkfnalelddsdlaifi
aviilsgdrpgllnvkpiediqdnllqalelqlklnhpessqlfakllqkmtdlrqivte
hvqllqvikktetdmslhpllqeiykdly

Sequence, based on observed residues (ATOM records):

>d2p4yb_ a.123.1.1 (B:) Peroxisome proliferator activated receptor gamma, PPAR-gamma {Human (Homo sapiens) [TaxId: 9606]}
adlralakhlydsyiksfpltkakarailspfviydmnsairifqgcqfrsveavqeite
yaksipgfvnldlndqvtllkygvheiiytmlaslmnkdgvlisegqgfmtreflkslrk
pfgdfmepkfefavkfnalelddsdlaifiaviilsgdrpgllnvkpiediqdnllqale
lqlklnhpessqlfakllqkmtdlrqivtehvqllhpllqeiykdly

Timeline for d2p4yb_:

• d2p4yb_ first appeared in SCOP 1.75, called d2p4yb1
  
• d2p4yb_ appears in SCOPe 2.04
  
• d2p4yb_ appears in SCOPe 2.06
  
• d2p4yb_ appears in the current release, SCOPe 2.08