SCOPe 2.01: Superfamily d.294.1: EndoU-like

Lineage for Superfamily d.294.1: EndoU-like

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.294: EndoU-like [142876] (1 superfamily)
   comprises several helices and two three-stranded antiparallel beta-sheets; similar architecture to the RNase A-like fold (54075)

4. Superfamily d.294.1: EndoU-like [142877] (2 families)
   similarity to the RNase A-like superfamily (54076) extends to the active site location and architecture; the two structural cores of the RNase A and EndoU superfamilies are interrelated by a topological permutation - transposition of two pereferial beta-strands, suggesting possible distant homology of the two superfamilies (and their unification in a hyperfamily)

Families:

1. d.294.1.1: Eukaryotic EndoU ribonuclease [142878] (2 proteins)
   PfamB PB010233; common fold decorated with additional structures

2. d.294.1.2: Nsp15 C-terminal domain-like [142881] (1 protein)
   PfamB PB001946

More info for Superfamily d.294.1: EndoU-like

Timeline for Superfamily d.294.1: EndoU-like:

• Superfamily d.294.1: EndoU-like first appeared in SCOP 1.73
  
• Superfamily d.294.1: EndoU-like appears in SCOP 1.75
  
• Superfamily d.294.1: EndoU-like appears in SCOPe 2.02
  
• Superfamily d.294.1: EndoU-like appears in the current release, SCOPe 2.08