SCOPe 2.06: Domain d2pfha_: 2pfh A:

Lineage for d2pfha_ (2pfh A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (135 PDB entries)
   Uniprot P15121

8. Domain d2pfha_: 2pfh A: [139671]
   automated match to d1pwla_
   complexed with cit, cl, fid, ldt, ndp

Details for d2pfha_

PDB Entry: 2pfh, 0.85 Å

PDB Description: Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594.

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d2pfha_:

Sequence; same for both SEQRES and ATOM records:

>d2pfha_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfhe

Timeline for d2pfha_:

• d2pfha_ first appeared in SCOP 1.73, called d2pfha1
  
• d2pfha_ appears in SCOPe 2.05
  
• d2pfha_ appears in SCOPe 2.07
  
• d2pfha_ appears in the current release, SCOPe 2.08