SCOPe 2.08: Domain d2o4sb_: 2o4s B:

Lineage for d2o4sb_ (2o4s B:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.1: Retroviral protease (retropepsin) [50631] (9 proteins)
   dimer of identical mono-domain chains, each containing (6,10) barrel

6. Protein Human immunodeficiency virus type 1 protease [50632] (9 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [50633] (590 PDB entries)
   Uniprot P35963 57-155 ! Uniprot P04587 69-167 ! Uniprot P03366 69-167 ! Uniprot P03367 69-167 ! Uniprot P03368 69-167

8. Domain d2o4sb_: 2o4s B: [138915]
   automated match to d3tlha_
   complexed with ab1, cl, gol

Details for d2o4sb_

PDB Entry: 2o4s, 1.54 Å

PDB Description: crystal structure of hiv-1 protease (q7k) in complex with lopinavir

PDB Compounds: (B:) Protease

SCOPe Domain Sequences for d2o4sb_:

Sequence; same for both SEQRES and ATOM records:

>d2o4sb_ b.50.1.1 (B:) Human immunodeficiency virus type 1 protease {Human immunodeficiency virus type 1 [TaxId: 11676]}
pqitlwkrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigctlnf

Timeline for d2o4sb_:

• d2o4sb_ first appeared in SCOP 1.73, called d2o4sb1
  
• d2o4sb_ appears in SCOPe 2.07