SCOPe 2.03: Domain d2j6ma1: 2j6m A:697-1018

Lineage for d2j6ma1 (2j6m A:697-1018)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein EGF receptor tyrosine kinase, Erbb-1 [82795] (1 species)
   PTK group; EGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [82796] (38 PDB entries)
   Uniprot P00533 702-1018

8. Domain d2j6ma1: 2j6m A:697-1018 [138088]
   automatically matched to d1m14a_
   complexed with aee

Details for d2j6ma1

PDB Entry: 2j6m, 3.1 Å

PDB Description: crystal structure of egfr kinase domain in complex with aee788

PDB Compounds: (A:) Epidermal growth factor receptor

SCOPe Domain Sequences for d2j6ma1:

Sequence, based on SEQRES records:

>d2j6ma1 d.144.1.7 (A:697-1018) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsn
fyralmdeedmddvvdadeyli

Sequence, based on observed residues (ATOM records):

>d2j6ma1 d.144.1.7 (A:697-1018) EGF receptor tyrosine kinase, Erbb-1 {Human (Homo sapiens) [TaxId: 9606]}
eapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspkan
keildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqylln
wcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyhaeggkv
pikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqp
pictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgddeedmddvvdad
eyli

Timeline for d2j6ma1:

• d2j6ma1 first appeared in SCOP 1.73
  
• d2j6ma1 appears in SCOPe 2.02
  
• d2j6ma1 is called d2j6ma_ in SCOPe 2.04
  
• d2j6ma1 appears in the current release, SCOPe 2.08, called d2j6ma_