SCOPe 2.06: Domain d2h8mb_: 2h8m B:

Lineage for d2h8mb_ (2h8m B:)

1. Root: SCOPe 2.06

2. Class d: Alpha and beta proteins (a+b) [53931] (385 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (5 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (2 proteins)

6. Protein HSP90 [55876] (3 species)

7. Species Dog (Canis familiaris) [TaxId:9615] [103225] (26 PDB entries)
   Uniprot P41148 76-285; Endoplasmin, GRP94

8. Domain d2h8mb_: 2h8m B: [136244]
   automated match to d1u2oa_
   complexed with 1pe, nei, pg4

Details for d2h8mb_

PDB Entry: 2h8m, 1.8 Å

PDB Description: n-domain of grp94 in complex with the 2-iodo-neca

PDB Compounds: (B:) Endoplasmin

SCOPe Domain Sequences for d2h8mb_:

Sequence, based on SEQRES records:

>d2h8mb_ d.122.1.1 (B:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

Sequence, based on observed residues (ATOM records):

>d2h8mb_ d.122.1.1 (B:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtieflnkmtetseligqfgvgfysaflva
dkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdyleldtikn
lvkkysqfinfpiyvwssktktvwdwelmn

Timeline for d2h8mb_:

• d2h8mb_ first appeared in SCOP 1.73, called d2h8mb1
  
• d2h8mb_ appears in SCOPe 2.05
  
• d2h8mb_ appears in SCOPe 2.07
  
• d2h8mb_ appears in the current release, SCOPe 2.08