SCOPe 2.08: Domain d2gfsa_: 2gfs A:

Lineage for d2gfsa_ (2gfs A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase p38 [56129] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56130] (204 PDB entries)

8. Domain d2gfsa_: 2gfs A: [135109]
   automated match to d1a9u__
   complexed with pqb

Details for d2gfsa_

PDB Entry: 2gfs, 1.75 Å

PDB Description: p38 kinase crystal structure in complex with ro3201195

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d2gfsa_:

Sequence, based on SEQRES records:

>d2gfsa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d2gfsa_ d.144.1.7 (A:) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfhtddemtgyvatrwy
rapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellk
kissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayf
aqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Timeline for d2gfsa_:

• d2gfsa_ first appeared in SCOP 1.73, called d2gfsa1
  
• d2gfsa_ appears in SCOPe 2.07