Lineage for d2gfsa1 (2gfs A:5-352)

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 734668Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 734669Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 734710Family d.144.1.7: Protein kinases, catalytic subunit [88854] (61 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 735287Protein MAP kinase p38 [56129] (2 species)
    CMGC group; ERK/MAPK subfamily; serine/threonine kinase
  7. 735288Species Human (Homo sapiens) [TaxId:9606] [56130] (41 PDB entries)
  8. 735289Domain d2gfsa1: 2gfs A:5-352 [135109]
    automatically matched to d1a9u__
    complexed with pqb

Details for d2gfsa1

PDB Entry: 2gfs (more details), 1.75 Å

PDB Description: p38 kinase crystal structure in complex with ro3201195
PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOP Domain Sequences for d2gfsa1:

Sequence, based on SEQRES records: (download)

>d2gfsa1 d.144.1.7 (A:5-352) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyva
trwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpga
ellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqala
hayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records): (download)

>d2gfsa1 d.144.1.7 (A:5-352) MAP kinase p38 {Human (Homo sapiens) [TaxId: 9606]}
rptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsiih
akrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltd
dhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfhtddemtgyvatrwy
rapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellk
kissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayf
aqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

SCOP Domain Coordinates for d2gfsa1:

Click to download the PDB-style file with coordinates for d2gfsa1.
(The format of our PDB-style files is described here.)

Timeline for d2gfsa1: