SCOPe 2.01: Domain d2gfda_: 2gfd A:

Lineage for d2gfda_ (2gfd A:)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.122: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55873] (1 superfamily)
   8-stranded mixed beta-sheet; 2 layers: alpha/beta

4. Superfamily d.122.1: ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase [55874] (4 families)

5. Family d.122.1.1: Heat shock protein 90, HSP90, N-terminal domain [55875] (2 proteins)

6. Protein HSP90 [55876] (3 species)

7. Species Dog (Canis familiaris) [TaxId:9615] [103225] (22 PDB entries)
   Uniprot P41148 76-285; Endoplasmin, GRP94

8. Domain d2gfda_: 2gfd A: [135094]
   automated match to d1u2oa_
   complexed with 1pe, pg4, rda

Details for d2gfda_

PDB Entry: 2gfd, 2.3 Å

PDB Description: grp94 in complex with the novel hsp90 inhibitor radamide

PDB Compounds: (A:) Endoplasmin

SCOPe Domain Sequences for d2gfda_:

Sequence, based on SEQRES records:

>d2gfda_ d.122.1.1 (A:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtiaksgtseflnkmteaqedgqstselig
qfgvgfysaflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlke
easdyleldtiknlvkkysqfinfpiyvwssktggggktvwdwelmn

Sequence, based on observed residues (ATOM records):

>d2gfda_ d.122.1.1 (A:) HSP90 {Dog (Canis familiaris) [TaxId: 9615]}
ekfafqaevnrmmkliinslyknkeiflrelisnasdaldkirlisltdenalagneelt
vkikcdkeknllhvtdtgvgmtreelvknlgtikgtseflnkmtestseligqfgvgfys
aflvadkvivtskhnndtqhiwesdsnefsviadprgntlgrgttitlvlkeeasdylel
dtiknlvkkysqfinfpiyvwssktktvwdwelmn

Timeline for d2gfda_:

• d2gfda_ first appeared in SCOP 1.73, called d2gfda1
  
• d2gfda_ was called d2gfda1 in SCOP 1.75
  
• d2gfda_ appears in SCOPe 2.02
  
• d2gfda_ appears in the current release, SCOPe 2.08