Lineage for d2chma1 (2chm A:537-858)

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2014835Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 2014836Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) (S)
  5. 2014926Family a.211.1.2: PDEase [48548] (7 protein domains)
    Pfam PF00233; multihelical; can be divided into three subdomains
  6. 2015121Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)
  7. 2015122Species Human (Homo sapiens) [TaxId:9606] [101440] (18 PDB entries)
    Uniprot O76074 534-860
  8. 2015125Domain d2chma1: 2chm A:537-858 [130472]
    complexed with 3p4, mes, mg, zn

Details for d2chma1

PDB Entry: 2chm (more details), 1.6 Å

PDB Description: crystal structure of n2 substituted pyrazolo pyrimidinones-a flipped binding mode in pde5
PDB Compounds: (A:) cgmp-specific 3', 5'-cyclic phosphodiesterase, camp-specific 3', 5'-cyclic phosphodiesterase 4b

SCOPe Domain Sequences for d2chma1:

Sequence; same for both SEQRES and ATOM records: (download)

>d2chma1 a.211.1.2 (A:537-858) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2chma1:

Click to download the PDB-style file with coordinates for d2chma1.
(The format of our PDB-style files is described here.)

Timeline for d2chma1: