SCOPe 2.04: Domain d2c2sb_: 2c2s B:

Lineage for d2c2sb_ (2c2s B:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
   3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest

4. Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families)

5. Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins)

6. Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [53607] (61 PDB entries)

8. Domain d2c2sb_: 2c2s B: [129683]
   automated match to d1drf__
   complexed with 34b, gol, ndp

Details for d2c2sb_

PDB Entry: 2c2s, 1.4 Å

PDB Description: human dihydrofolate reductase complexed with nadph and 2,4-diamino-5- (1-o-carboranylmethyl)-6-methylpyrimidine, a novel boron containing, nonclassical antifolate

PDB Compounds: (B:) dihydrofolate reductase

SCOPe Domain Sequences for d2c2sb_:

Sequence; same for both SEQRES and ATOM records:

>d2c2sb_ c.71.1.1 (B:) Dihydrofolate reductases, eukaryotic type {Human (Homo sapiens) [TaxId: 9606]}
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd

Timeline for d2c2sb_:

• d2c2sb_ first appeared in SCOP 1.73, called d2c2sb1
  
• d2c2sb_ appears in SCOPe 2.03
  
• d2c2sb_ appears in SCOPe 2.05
  
• d2c2sb_ appears in the current release, SCOPe 2.08