SCOPe 2.08: Domain d2aeph1: 2aep H:114-190

Lineage for d2aeph1 (2aep H:114-190)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Mouse (Mus musculus) [TaxId:10090] [88576] (391 PDB entries)
   Uniprot P01864 # GCAB_MOUSE Ig gamma-2A chain C region secreted form (B allele) ! Uniprot P01863 #GCAA_MOUSE Ig gamma-2A chain C region, A allele; 86% sequence identity ! SQ NA # natural chimera; best hits are: Uniprot P01751 (Ig heavy chain V region B1-8/186-2) and Uniprot P01864 (Ig gamma-2A chain C region secreted form) ! Uniprot P01868 # GC1_MOUSE Ig gamma-1 chain C region secreted form ! Uniprot P01864 # GCAB_MOUSE (P01864) Ig gamma-2A chain C region ! Uniprot P01837 # KAC_MOUSE (P01837) Ig kappa chain C region ! Uniprot P01863 # GCAA_MOUSE Ig gamma-2A chain C region, A allele ! SQ NA # part of Fab 28 against HIV-1 RT ! Uniprot P01868 # ! GC1_MOUSE Ig gamma-1 chain C region secreted form

8. Domain d2aeph1: 2aep H:114-190 [126639]
   Other proteins in same PDB: d2aepa1, d2aepl1
   automatically matched to d1mh5b2
   complexed with ca, glc, man, nag, so4
   fragment; missing more than one-third of the common structure and/or sequence

Details for d2aeph1

PDB Entry: 2aep, 2.1 Å

PDB Description: an epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the na-antibody complex.

PDB Compounds: (H:) Fab heavy chain

SCOPe Domain Sequences for d2aeph1:

Sequence, based on SEQRES records:

>d2aeph1 b.1.1.2 (H:114-190) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Mouse (Mus musculus) [TaxId: 10090]}
akttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsd
lytlsss

Sequence, based on observed residues (ATOM records):

>d2aeph1 b.1.1.2 (H:114-190) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Mouse (Mus musculus) [TaxId: 10090]}
aktfpepvtltgvhtfpatlsss

Timeline for d2aeph1:

• d2aeph1 first appeared in SCOP 1.73
  
• d2aeph1 appears in SCOPe 2.07