PDB entry 2aep

View 2aep on RCSB PDB site
Description: An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex.
Class: immune system
Keywords: influenza virus neuraminidase-fab complex, immune system
Deposited on 2005-07-23, released 2005-12-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neuraminidase
    Species: Influenza A virus [TaxId:228928]
    Database cross-references and differences (RAF-indexed):
    • GB AAP23239 (Start-394)
    Domains in SCOPe 2.08: d2aepa1
  • Chain 'H':
    Compound: Fab heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2AEP (0-End)
    Domains in SCOPe 2.08: d2aeph1
  • Chain 'L':
    Compound: Fab light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 2AEP (0-End)
    Domains in SCOPe 2.08: d2aepl1
  • Heterogens: GLC, NAG, CA, SO4, MAN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2aepA (A:)
    keicpklaeyrnwskpqckitgfapfskdnsirlsaggdiwvtrepyvscdpdkcyqfal
    gqgttlnnrhsndtvhdrtpyrtllmnelgvpfhlgtkqvciawsssschdgkawlhvcv
    tghdenatasfiydgrlvdsigswskkilrtqesecvcingtctvvmtdgsasgradtki
    lfieegkivhisplsgsaqhveecscyprypgvrcvcrdnwkgsnrpivdinvkdysivs
    syvcsglvgdtprkndssssshclnpnneegghgvkgwafddgndvwmgrtisekfrsgy
    etfkviegwskpnsklqinrqvivdrgnrsgysgifsvegkscinrcfyvelirgrkqet
    evwwtsnsivvfcgtsgtygtgswpdgadinlmpi
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aepA (A:)
    aeyrnwskpqckitgfapfskdnsirlsaggdiwvtrepyvscdpdkcyqfalgqgttln
    nrhsndtvhdrtpyrtllmnelgvpfhlgtkqvciawsssschdgkawlhvcvtghdena
    tasfiydgrlvdsigswskkilrtqesecvcingtctvvmtdgsasgradtkilfieegk
    ivhisplsgsaqhveecscyprypgvrcvcrdnwkgsnrpivdinvkdysivssyvcsgl
    vgdtprkndssssshclnpnneegghgvkgwafddgndvwmgrtisekfrsgyetfkvie
    gwskpnsklqinrqvivdrgnrsgysgifsvegkscinrcfyvelirgrkqetevwwtsn
    sivvfcgtsgtygtgswpdgadinlmpi
    

  • Chain 'H':
    Sequence, based on SEQRES records: (download)
    >2aepH (H:)
    evklvesggglvqpggslslscatsgftfidyymswfrqppgkalewlglirnkgngytm
    eysaslkgrftisrdnsqsivylhmntltaedsatyycarvdygtnydywgqgttltvss
    akttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsd
    lytlsssvtvtsstwpsqsitcnvahpasstkvdkki
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aepH (H:)
    evklvesggglvqpggslslscatsgftfidyymswfrqppgkalewlglirnkgngytm
    eysaslkgrftisrdnsqsivylhmntltaedsatyycarvdygtnydywgqgttltvss
    aktfpepvtltgvhtfpatlsss
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2aepL (L:)
    dilmtqsqkflstsvgdrvsvtckasqnvgtnvawyqkkpgqspkplmysasyrysgvpd
    rftgsgsgtdftltisnvqsedlaeyfcqqfnrypltfgsgtklelkradaaptvsifpp
    sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
    ltkdeyerhnsytceathktstspivksfnrnec
    

    Sequence, based on observed residues (ATOM records): (download)
    >2aepL (L:)
    dilmtqsqkflstsvgdrvsvtckasqnvgtnvawyqkkpgqspkplmysasyrysgvpd
    rftgsgsgtdftltisnvqsedlaeyfcqqfnrypltfgsgtklelkradaaplnnfypk
    dtdqdskds