SCOP 1.75: Domain d1vcub_: 1vcu B:

Lineage for d1vcub_ (1vcu B:)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
   consists of six 4-stranded beta-sheet motifs; meander

4. Superfamily b.68.1: Sialidases [50939] (2 families)

5. Family b.68.1.1: Sialidases (neuraminidases) [50940] (9 proteins)

6. Protein Sialidase 2 (Neu2) [117274] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117275] (8 PDB entries)
   Uniprot Q9Y3R4

8. Domain d1vcub_: 1vcu B: [113611]
   complexed with dan, epe

Details for d1vcub_

PDB Entry: 1vcu, 2.85 Å

PDB Description: structure of the human cytosolic sialidase neu2 in complex with the inhibitor dana

PDB Compounds: (B:) Sialidase 2

SCOP Domain Sequences for d1vcub_:

Sequence, based on SEQRES records:

>d1vcub_ b.68.1.1 (B:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshl
rarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpth
swqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandye
eivflmftlkqafpaey

Sequence, based on observed residues (ATOM records):

>d1vcub_ b.68.1.1 (B:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvteqqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshl
rarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprspaqwllythpthswqr
adlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivf
lmftlkqafpaey

Timeline for d1vcub_:

• d1vcub_ first appeared in SCOP 1.71
  
• d1vcub_ appears in SCOP 1.73
  
• d1vcub_ appears in SCOPe 2.01
  
• d1vcub_ appears in the current release, SCOPe 2.08