SCOP 1.75: Domain d1vl6c1: 1vl6 C:155-376

Lineage for d1vl6c1 (1vl6 C:155-376)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.7: Aminoacid dehydrogenase-like, C-terminal domain [51883] (11 proteins)
   extra N-terminal helix displaces the C-terminal helix (following strand 6) from its usual position creating a family nicotineamide-binding site

6. Protein Malate oxidoreductase (malic enzyme) [110434] (1 species)

7. Species Thermotoga maritima [TaxId:2336] [110435] (2 PDB entries)
   Uniprot Q9WZ12

8. Domain d1vl6c1: 1vl6 C:155-376 [108728]
   Other proteins in same PDB: d1vl6a2, d1vl6b2, d1vl6c2, d1vl6d2
   Structural genomics target

Details for d1vl6c1

PDB Entry: 1vl6, 2.61 Å

PDB Description: Crystal structure of NAD-dependent malic enzyme (TM0542) from Thermotoga maritima at 2.61 A resolution

PDB Compounds: (C:) Malate oxidoreductase

SCOP Domain Sequences for d1vl6c1:

Sequence; same for both SEQRES and ATOM records:

>d1vl6c1 c.2.1.7 (C:155-376) Malate oxidoreductase (malic enzyme) {Thermotoga maritima [TaxId: 2336]}
dqqgtavvvsaaflnalkltekkieevkvvvngigaagynivkflldlgvknvvavdrkg
ilnendpetclneyhleiaritnperlsgdletalegadffigvsrgnilkpewikkmsr
kpvifalanpvpeidpelareagafivatgrsdhpnqvnnllafpgimkgavekrskitk
nmllsaveaiarscepeperiipeafdmkvhlnvytavkgsa

Timeline for d1vl6c1:

• d1vl6c1 first appeared in SCOP 1.69
  
• d1vl6c1 appears in SCOP 1.73
  
• d1vl6c1 appears in SCOPe 2.01
  
• d1vl6c1 appears in the current release, SCOPe 2.08