SCOPe 2.04: Domain d1t41a_: 1t41 A:

Lineage for d1t41a_ (1t41 A:)

1. Root: SCOPe 2.04

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.7: NAD(P)-linked oxidoreductase [51430] (2 families)

5. Family c.1.7.1: Aldo-keto reductases (NADP) [51431] (16 proteins)
   Common fold covers whole protein structure

6. Protein Aldose reductase (aldehyde reductase) [51436] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [51437] (102 PDB entries)
   Uniprot P15121

8. Domain d1t41a_: 1t41 A: [106391]
   complexed with id5, nap

Details for d1t41a_

PDB Entry: 1t41, 1.05 Å

PDB Description: crystal structure of human aldose reductase complexed with nadp and idd552

PDB Compounds: (A:) aldose reductase

SCOPe Domain Sequences for d1t41a_:

Sequence; same for both SEQRES and ATOM records:

>d1t41a_ c.1.7.1 (A:) Aldose reductase (aldehyde reductase) {Human (Homo sapiens) [TaxId: 9606]}
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef

Timeline for d1t41a_:

• d1t41a_ first appeared in SCOP 1.69
  
• d1t41a_ appears in SCOPe 2.03
  
• d1t41a_ appears in SCOPe 2.05
  
• d1t41a_ appears in the current release, SCOPe 2.08