SCOPe 2.08: Domain d1sk6c_: 1sk6 C:

Lineage for d1sk6c_ (1sk6 C:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.41: Adenylylcyclase toxin (the edema factor) [81299] (1 superfamily)
   3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha

4. Superfamily e.41.1: Adenylylcyclase toxin (the edema factor) [81298] (1 family)
   Domain 1 has topological and active site similarity to the Nucleotidyltransferases (eg. 1kny N-domain); domain 3 binds calmodulin

5. Family e.41.1.1: Adenylylcyclase toxin (the edema factor) [69887] (1 protein)
   decorated with many insertions and the C-terminal domain

6. Protein Adenylylcyclase toxin (the edema factor) [69888] (1 species)

7. Species Anthrax bacillus (Bacillus anthracis) [TaxId:1392] [69889] (7 PDB entries)
   Uniprot P40136

8. Domain d1sk6c_: 1sk6 C: [105667]
   Other proteins in same PDB: d1sk6d_, d1sk6e_, d1sk6f_
   complexed with ca, cmp, pop, yb

Details for d1sk6c_

PDB Entry: 1sk6, 3.2 Å

PDB Description: crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with calmodulin, 3',5' cyclic amp (camp), and pyrophosphate

PDB Compounds: (C:) calmodulin-sensitive adenylate cyclase

SCOPe Domain Sequences for d1sk6c_:

Sequence, based on SEQRES records:

>d1sk6c_ e.41.1.1 (C:) Adenylylcyclase toxin (the edema factor) {Anthrax bacillus (Bacillus anthracis) [TaxId: 1392]}
ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
akintiptsaefiknlssirrssnvgvykdsgdkdefakkesvkkiagylsdyynsanhi
fsqekkrkisifrgiqayneienvlkskqiapeyknyfqylkeritnqvqlllthqksni
efkllykqlnftenetdnfevfqkiid

Sequence, based on observed residues (ATOM records):

>d1sk6c_ e.41.1.1 (C:) Adenylylcyclase toxin (the edema factor) {Anthrax bacillus (Bacillus anthracis) [TaxId: 1392]}
ridvlkgekalkasglvpehadafkkiarelntyilfrpvnklatnliksgvatkglnvh
gkssdwgpvagyipfdqdlskkhgqqlavekgnlenkksitehegeigkiplkldhlrie
elkengiilkgkkeidngkkyyllesnnqvyefrisdennevqyktkegkitvlgekfnw
rnievmaknvegvlkpltadydlfalapslteikkqipqkewdkvvntpnslekqkgvtn
llikygierkpdstkgtlsnwqkqmldrlneavkytgytggdvvnhgteqdneefpekdn
eifiinpegefiltknwemtgrfieknitgkdylyyfnrsynkiapgnkayiewtdpitk
akintiptsaefiknlssirrssvkkiagylsdyynsanhifsqekkrkisifrgiqayn
eienvlkskqiapeyknyfqylkeritnqvqlllthqfkllykqlnftenetdnfevfqk
iid

Timeline for d1sk6c_:

• d1sk6c_ first appeared in SCOP 1.69
  
• d1sk6c_ appears in SCOPe 2.07