Lineage for Superfamily e.41.1: Adenylylcyclase toxin (the edema factor)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.41: Adenylylcyclase toxin (the edema factor) [81299] (1 superfamily) 3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha

4. Superfamily e.41.1: Adenylylcyclase toxin (the edema factor) [81298] (1 family) Domain 1 has topological and active site similarity to the Nucleotidyltransferases (eg. 1kny N-domain); domain 3 binds calmodulin