Lineage for d1rr8c1 (1rr8 C:431-608,C:708-765)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2999834Fold d.163: DNA breaking-rejoining enzymes [56348] (1 superfamily)
    core: alpha3-beta3-alpha4; one side of beta-sheet is exposed
  4. 2999835Superfamily d.163.1: DNA breaking-rejoining enzymes [56349] (2 families) (S)
  5. 2999937Family d.163.1.2: Eukaryotic DNA topoisomerase I, catalytic core [56361] (1 protein)
  6. 2999938Protein Eukaryotic DNA topoisomerase I, catalytic core [56362] (2 species)
  7. 2999939Species Human (Homo sapiens) [TaxId:9606] [56363] (15 PDB entries)
    Uniprot P11387 203-765 ! Uniprot P11387 203-767
  8. 2999945Domain d1rr8c1: 1rr8 C:431-608,C:708-765 [105076]
    Other proteins in same PDB: d1rr8c2, d1rr8c3
    protein/DNA complex; complexed with ttg; mutant

Details for d1rr8c1

PDB Entry: 1rr8 (more details), 2.6 Å

PDB Description: structural mechanisms of camptothecin resistance by mutations in human topoisomerase i
PDB Compounds: (C:) DNA topoisomerase I

SCOPe Domain Sequences for d1rr8c1:

Sequence; same for both SEQRES and ATOM records: (download)

>d1rr8c1 d.163.1.2 (C:431-608,C:708-765) Eukaryotic DNA topoisomerase I, catalytic core {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d1rr8c1:

Click to download the PDB-style file with coordinates for d1rr8c1.
(The format of our PDB-style files is described here.)

Timeline for d1rr8c1: