SCOP 1.73: Superfamily a.204.1: all-alpha NTP pyrophosphatases

Lineage for Superfamily a.204.1: all-alpha NTP pyrophosphatases

1. Root: SCOP 1.73

2. Class a: All alpha proteins [46456] (258 folds)

3. Fold a.204: all-alpha NTP pyrophosphatases [101385] (1 superfamily)
   multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer

4. Superfamily a.204.1: all-alpha NTP pyrophosphatases [101386] (4 families)
   basic module consist of 5 active site-forming helices; four from one subunit/structural repeat; the fifth from the other subunit/repeat

Families:

1. a.204.1.1: Type II deoxyuridine triphosphatase [101387] (1 protein)
   one subunit comprises two degenerate structural repeats, organised into the "rigid" and "mobile" subdomains

2. a.204.1.2: MazG-like [116993] (3 proteins)
   Pfam PF03819

3. a.204.1.3: AF0060-like [140794] (1 protein)
   consists of a single member with an orphan sequence; "circular permutation" of putative active site residues: the catalytic lysine resides in the N-terminal helix instead of the missing in this family C-terminal helix; probable biological unit is a tertramer, distinct from the MazG family tetramer

4. a.204.1.4: HisE-like (PRA-PH) [140797] (1 protein)
   Pfam PF01503

More info for Superfamily a.204.1: all-alpha NTP pyrophosphatases

Timeline for Superfamily a.204.1: all-alpha NTP pyrophosphatases:

• Superfamily a.204.1: all-alpha NTP pyrophosphatases first appeared in SCOP 1.67, called Superfamily a.204.1: Type II deoxyuridine triphosphatase
  
• Superfamily a.204.1: all-alpha NTP pyrophosphatases appears in SCOP 1.71
  
• Superfamily a.204.1: all-alpha NTP pyrophosphatases appears in SCOP 1.75
  
• Superfamily a.204.1: all-alpha NTP pyrophosphatases appears in the current release, SCOPe 2.08