Lineage for Superfamily a.204.1: all-alpha NTP pyrophosphatases

  1. Root: SCOPe 2.06
  2. 1976409Class a: All alpha proteins [46456] (289 folds)
  3. 2014645Fold a.204: all-alpha NTP pyrophosphatases [101385] (1 superfamily)
    multihelical: dimeric 4-helical bundle surrounded by other helices; oligomerizes further in a tetramer
  4. 2014646Superfamily a.204.1: all-alpha NTP pyrophosphatases [101386] (5 families) (S)
    basic module consist of 5 active site-forming helices; four from one subunit/structural repeat; the fifth from the other subunit/repeat

Families:

  1. 2014647a.204.1.1: Type II deoxyuridine triphosphatase [101387] (1 protein)
    one subunit comprises two degenerate structural repeats, organised into the "rigid" and "mobile" subdomains
  2. 2014659a.204.1.2: MazG-like [116993] (4 protein domains)
    Pfam PF03819
  3. 2014683a.204.1.3: AF0060-like [140794] (1 protein)
    consists of a single member with an orphan sequence; "circular permutation" of putative active site residues: the catalytic lysine resides in the N-terminal helix instead of the missing in this family C-terminal helix; probable biological unit is a tertramer, distinct from the MazG family tetramer
  4. 2014688a.204.1.4: HisE-like (PRA-PH) [140797] (1 protein)
    Pfam PF01503
  5. 2014724a.204.1.0: automated matches [191410] (1 protein)
    not a true family

More info for Superfamily a.204.1: all-alpha NTP pyrophosphatases

Timeline for Superfamily a.204.1: all-alpha NTP pyrophosphatases: