Lineage for d3tsea_ (3tse A:)

  1. Root: SCOPe 2.03
  2. 1253684Class a: All alpha proteins [46456] (284 folds)
  3. 1285679Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
    multihelical; consists of two different alpha-helical bundles
  4. 1285680Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families) (S)
  5. 1285765Family a.211.1.2: PDEase [48548] (7 proteins)
    Pfam PF00233; multihelical; can be divided into three subdomains
  6. 1286002Protein automated matches [190370] (1 species)
    not a true protein
  7. 1286003Species Human (Homo sapiens) [TaxId:9606] [187208] (22 PDB entries)
  8. 1286012Domain d3tsea_: 3tse A: [217024]
    automated match to d3siea_
    complexed with 5eo, mg, zn

Details for d3tsea_

PDB Entry: 3tse (more details), 2.14 Å

PDB Description: crystal structure of the pde5a1 catalytic domain in complex with novel inhibitors
PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d3tsea_:

Sequence, based on SEQRES records: (download)

>d3tsea_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttl
kiikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwp
iqqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealt
hvsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records): (download)

>d3tsea_ a.211.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
meetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhe
vlcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalsh
dldhrgvnnsyiqrsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatd
lalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvat
effdqgknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

SCOPe Domain Coordinates for d3tsea_:

Click to download the PDB-style file with coordinates for d3tsea_.
(The format of our PDB-style files is described here.)

Timeline for d3tsea_: