PDB entry 8kme

View 8kme on RCSB PDB site
Description: crystal structure of human alpha-thrombin inhibited with sel2770.
Class: hydrolase/hydrolase inhibitor
Keywords: thrombin, hydrolase-hydrolase inhibitor complex, selectide
Deposited on 1999-03-21, released 1999-03-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-04, with a file datestamp of 2017-09-29.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain '1':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8kme.1
  • Chain '2':
    Compound: thrombin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d8kme.1
  • Chain '3':
    Compound: n-acetylhirudin
    Database cross-references and differences (RAF-indexed):
    • PDB 8KME (0-9)
  • Chain '4':
    Compound: sel2770
    Database cross-references and differences (RAF-indexed):
    • PDB 8KME
  • Heterogens: NA, HOH

PDB Chain Sequences:

  • Chain '1':
    Sequence, based on SEQRES records: (download) 
    >8kme1 (1:)
tfgsgeadcglrplfekksledkterellesyidgr

    Sequence, based on observed residues (ATOM records): (download) 
    >8kme1 (1:)
adcglrplfekksledkterellesy

  • Chain '2':
    Sequence, based on SEQRES records: (download) 
    >8kme2 (2:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketwtanvgkgqpsvlqvvnlpiverpvckdstrir
itdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfy
thvfrlkkwiqkvidqfge

    Sequence, based on observed residues (ATOM records): (download) 
    >8kme2 (2:)
ivegsdaeigmspwqvmlfrkspqellcgaslisdrwvltaahcllyppwdknftendll
vrigkhsrtryerniekismlekiyihprynwrenldrdialmklkkpvafsdyihpvcl
pdretaasllqagykgrvtgwgnlketgqpsvlqvvnlpiverpvckdstriritdnmfc
agykpdegkrgdacegdsggpfvmkspfnnrwyqmgivswgegcdrdgkygfythvfrlk
kwiqkvidqf

  • Chain '3':
    No sequence available.

  • Chain '4':
    No sequence available.