SCOPe 2.08: Domain d8kme.1: 8kme 1:,2:

Lineage for d8kme.1 (8kme 1:,2:)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.47: Trypsin-like serine proteases [50493] (1 superfamily)
   barrel, closed; n=6, S=8; greek-key
   duplication: consists of two domains of the same fold

4. Superfamily b.47.1: Trypsin-like serine proteases [50494] (5 families)

5. Family b.47.1.2: Eukaryotic proteases [50514] (49 proteins)

6. Protein Thrombin [50531] (2 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50532] (171 PDB entries)
   Uniprot P00734 331-361,364-421 ! Uniprot P00734 334-360 364-510 518-619 ! Uniprot P00734 328-620 ! Uniprot P00734 355-621 ! Uniprot P00734 328-620

8. Domain d8kme.1: 8kme 1:,2: [26129]
   complexed with na

Details for d8kme.1

PDB Entry: 8kme, 2.1 Å

PDB Description: crystal structure of human alpha-thrombin inhibited with sel2770.

PDB Compounds: (1:) thrombin, (2:) thrombin

SCOPe Domain Sequences for d8kme.1:

Sequence, based on SEQRES records:

>g8kme.1 b.47.1.2 (1:,2:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketwtanvg
kgqpsvlqvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmks
pfnnrwyqmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

Sequence, based on observed residues (ATOM records):

>g8kme.1 b.47.1.2 (1:,2:) Thrombin {Human (Homo sapiens) [TaxId: 9606]}
adcglrplfekksledkterellesyXivegsdaeigmspwqvmlfrkspqellcgasli
sdrwvltaahcllyppwdknftendllvrigkhsrtryerniekismlekiyihprynwr
enldrdialmklkkpvafsdyihpvclpdretaasllqagykgrvtgwgnlketgqpsvl
qvvnlpiverpvckdstriritdnmfcagykpdegkrgdacegdsggpfvmkspfnnrwy
qmgivswgegcdrdgkygfythvfrlkkwiqkvidqf

Timeline for d8kme.1:

• d8kme.1 first appeared (with stable ids) in SCOP 1.55
  
• d8kme.1 appears in SCOPe 2.07