PDB entry 7t2c

View 7t2c on RCSB PDB site
Description: Crystal structure of the B5 TCR in complex with HLA-DP4-Ply
Class: immune system
Keywords: TCR-pHLA complex, IMMUNE SYSTEM
Deposited on 2021-12-03, released 2022-12-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2022-12-28, with a file datestamp of 2022-12-23.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class II histocompatibility antigen, DP alpha 1 chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DPA1, HLA-DP1A, HLASB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7t2ca1, d7t2ca2
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DP beta 1 chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DPB1, HLA-DP1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7t2cb1, d7t2cb2
  • Chain 'C':
    Compound: Pneumolysin-derived peptide
    Species: Streptococcus pneumoniae [TaxId:1313]
    Gene: ply, SPD_1726
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q04IN8 (2-14)
      • cloning artifact (0-1)
  • Chain 'D':
    Compound: T cell receptor, B5, alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRAC, TCRA
    Database cross-references and differences (RAF-indexed):
    • PDB 7T2C (0-110)
    • Uniprot P01848 (111-203)
      • engineered mutation (157)
  • Chain 'E':
    Compound: T cell receptor, B5, beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: TRBC1
    Database cross-references and differences (RAF-indexed):
    • PDB 7T2C (0-119)
    • Uniprot P01850 (120-248)
      • engineered mutation (175)
      • engineered mutation (193)
    Domains in SCOPe 2.08: d7t2ce1, d7t2ce2
  • Heterogens: EDO, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7t2cA (A:)
ikadhvstyaafvqthrptgefmfefdedemfyvdldkketvwhleefgqafsfeaqggl
aniailnnnlntliqrsnhtqatndppevtvfpkepvelgqpntlichidkffppvlnvt
wlcngelvtegvaeslflprtdysfhkfhyltfvpsaedfydcrvehwgldqpllkhwea
q

    Sequence, based on observed residues (ATOM records): (download) 
    >7t2cA (A:)
ikadhvstyaafvqthrptgefmfefdedemfyvdldkketvwhleefgqafsfeaqggl
aniailnnnlntliqrsnhtqatndppevtvfpkepvelgqpntlichidkffppvlnvt
wlcngelvtegvaeslflprtdysfhkfhyltfvpsaedfydcrvehwgldqpllkhwea

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7t2cB (B:)
ratpenylfqgrqecyafngtqrfleryiynreefarfdsdvgefravtelgrpaaeywn
sqkdileekravpdrmcrhnyelggpmtlqrrvqprvnvspskkgplqhhnllvchvtdf
ypgsiqvrwflngqeetagvvstnlirngdwtfqilvmlemtpqqgdvytcqvehtslds
pvtvewka

    Sequence, based on observed residues (ATOM records): (download) 
    >7t2cB (B:)
tpenylfqgrqecyafngtqrfleryiynreefarfdsdvgefravtelgrpaaeywnsq
kdileekravpdrmcrhnyelggpmtlqrrvqprvnvspsnllvchvtdfypgsiqvrwf
lngqeetagvvstnlirngdwtfqilvmlemtpqqgdvytcqvehtsldspvtvew

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >7t2cE (E:)
gavvsqhpswvicksgtsvkiecrsldfqattmfwyrqfpkqslmlmatsnegskatyeq
gvekdkflinhasltlstltvtsahpedssfyicsardpggggssyeqyfgpgtrltvte
dlnkvfppevavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpq
plkeqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqiv
saeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >7t2cE (E:)
avvsqhpswvicksgtsvkiecrsldfqattmfwyrqfpkqslmlmatsnegskatyeqg
vekdkflinhasltlstltvtsahpedssfyicsardpggggssyeqyfgpgtrltvted
lnkvfppevavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvctdpqp
lkeqpalndsryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivs
aeawgrad