PDB entry 7m0v

View 7m0v on RCSB PDB site
Description: Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Cobimetinib
Class: transferase
Keywords: braf, mek1, transferase
Deposited on 2021-03-11, released 2021-04-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-04-21, with a file datestamp of 2021-04-16.
Experiment type: XRAY
Resolution: 3.16 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7m0va_
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02750
      • engineered mutation (221)
      • engineered mutation (225)
    Domains in SCOPe 2.07: d7m0vb_
  • Heterogens: ANP, EUI, MG

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7m0vA (A:)
gggrdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafkn
evgvlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqt
aqgmdylhaksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwm
apevirmqdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlsk
vrsncpkamkrlmaeclkkkrderplfpqilasiellarslpk

    Sequence, based on observed residues (ATOM records): (download) 
    >7m0vA (A:)
dweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlrkt
rhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdylh
aksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevirmq
dknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncpka
mkrlmaeclkkkrderplfpqilasiellarslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7m0vB (B:)
gggrmpkkkptpiqlnpapdgsavngtssaetnlealqkkleeleldeqqrkrleafltq
kqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelq
vlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikg
ltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidamanafvgtrsymsperlq
gthysvqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrp
lssygmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlm
vhafikrsdaeevdfagwlcstiglnqpstpthaagv

    Sequence, based on observed residues (ATOM records): (download) 
    >7m0vB (B:)
ldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihl
eikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagri
peqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidaman
afvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmpmaifel
ldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfag
wlcstiglnq