PDB entry 7ljc

View 7ljc on RCSB PDB site
Description: Allosteric modulator LY3154207 binding to SKF-81297-bound dopamine receptor 1 in complex with miniGs protein
Class: signaling protein
Keywords: Dopamine receptor 2, Gs protein, SKF-81297, PAM, LY3154207, SIGNALING PROTEIN
Deposited on 2021-01-28, released 2021-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: EM
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Engineered human Gs alpha subunit
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJC (Start-245)
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Rattus norvegicus [TaxId:10116]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7ljcb_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Bos taurus [TaxId:9913]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d7ljcg_
  • Chain 'N':
    Compound: Nanoboy 35
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 7LJC
    Domains in SCOPe 2.08: d7ljcn1, d7ljcn2
  • Chain 'R':
    Compound: D(1A) dopamine receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: DRD1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: G4C, SK0, CLR, PLM

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7ljcB (B:)
hhhhhhhhmgsllqseldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrt
rrtlrghlakiyamhwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayap
sgnyvacggldnicsiynlktregnvrvsrelaghtgylsccrflddnqivtssgdttca
lwdietgqqtttftghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghes
dinaicffpngnafatgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrllla
gyddfncnvwdalkadragvlaghdnrvsclgvtddgmavatgswdsflkiwn

    Sequence, based on observed residues (ATOM records): (download) 
    >7ljcB (B:)
eldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyamh
wgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnics
iynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttftg
htgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnafa
tgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalka
dragvlaghdnrvsclgvtddgmavatgswdsflkiwn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >7ljcG (G:)
asnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpf
rekkffc

    Sequence, based on observed residues (ATOM records): (download) 
    >7ljcG (G:)
tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfr

  • Chain 'N':
    Sequence, based on SEQRES records: (download) 
    >7ljcN (N:)
mqvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasis
ytgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrg
qgtqvtvsshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >7ljcN (N:)
qvqlqesggglvqpggslrlscaasgftfsnykmnwvrqapgkglewvsdisqsgasisy
tgsvkgrftisrdnakntlylqmnslkpedtavyycarcpapftrdcfdvtsttyayrgq
gtqvtvs

  • Chain 'R':
    No sequence available.