PDB entry 7kpb

View 7kpb on RCSB PDB site
Description: asymmetric hTNF-alpha
Class: CYTOKINE/Immune System
Keywords: Tumour necrosis factor alpha, TNF, asymmetric, protein-protein inhibitor, CYTOKINE, Fragment antibody, Fab, CYTOKINE-Immune System complex
Deposited on 2020-11-10, released 2021-01-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-02-03, with a file datestamp of 2021-01-29.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7kpba_
  • Chain 'B':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7kpbb_
  • Chain 'C':
    Compound: Tumor necrosis factor
    Species: Homo sapiens [TaxId:9606]
    Gene: TNF, TNFA, TNFSF2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7kpbc_
  • Chain 'E':
    Compound: Tumor necrosis factor receptor superfamily member 1A
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF1A, TNFAR, TNFR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19438
      • engineered mutation (13)
      • engineered mutation (141)
  • Chain 'F':
    Compound: Tumor necrosis factor receptor superfamily member 1A
    Species: Homo sapiens [TaxId:9606]
    Gene: TNFRSF1A, TNFAR, TNFR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19438 (1-End)
      • engineered mutation (13)
      • engineered mutation (141)
  • Chain 'H':
    Compound: Fab1974 - Heavy Chain
    Species: Mus musculus [TaxId:10090]
    Gene: mFab'nh CA_185_1974
    Database cross-references and differences (RAF-indexed):
    • PDB 7KPB (0-End)
  • Chain 'L':
    Compound: Fab1974 - Light Chain
    Species: Mus musculus [TaxId:10090]
    Gene: mFab'nh CA_185_1974
    Database cross-references and differences (RAF-indexed):
    • PDB 7KPB (0-End)
    Domains in SCOPe 2.07: d7kpbl1, d7kpbl2
  • Heterogens: D84, GOL, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7kpbA (A:)
svrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >7kpbA (A:)
srtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlf
kgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiylggvf
qlekgdrlsaeinrpdyldfaesgqvyfgiial

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7kpbB (B:)
svrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >7kpbB (B:)
rtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliysqvlfk
gqgcpsthvllthtisriavsyqtkvnllsaikspcakpwyepiylggvfqlekgdrlsa
einrpdyldfaesgqvyfgiial

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >7kpbC (C:)
svrsssrtpsdkpvahvvanpqaegqlqwlnrranallangvelrdnqlvvpseglyliy
sqvlfkgqgcpsthvllthtisriavsyqtkvnllsaikspcqretpegaeakpwyepiy
lggvfqlekgdrlsaeinrpdyldfaesgqvyfgiial

    Sequence, based on observed residues (ATOM records): (download) 
    >7kpbC (C:)
sdkpvahvvanpqaegqlqwlnrrllangvelrdnqlvvpseglyliysqvlfkgqgcps
thvllthtisriavsyqtkvnllsaikspcqakpwyepiylggvfqlekgdrlsaeinrp
dyldfaesgqvyfgiial

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >7kpbL (L:)
diqmtqspaslpaspeeivtitcqasqdignwlswyqqkpgkspqlliygatsladgvps
rfsasrsgtqyslkisrlqvedfgifyclqgqstpytfgagtklelkrtdaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records): (download) 
    >7kpbL (L:)
diqmtqspaslpaspeeivtitcqasqdignwlswyqqkpgkspqlliygatsladgvps
rfsasrsgtqyslkisrlqvedfgifyclqgqstpytfgagtklelkrtdaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrne