PDB entry 7jo3

View 7jo3 on RCSB PDB site
Description: Carbonic Anhydrase IX Mimic Complexed with N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pivalamide
Class: lyase/inhibitor
Keywords: Carbonic Anhydrase, CA Inhibitor, Structure Guided Drug Design, Carbonic Anhydrase II, Carbonic Anhydrase IX, CAII, CAIX, Sulfonamide, LYASE, LYASE-INHIBITOR complex
Deposited on 2020-08-05, released 2020-11-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-11-18, with a file datestamp of 2020-11-13.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: N/A
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CA2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00918 (Start-256)
      • engineered mutation (64)
      • engineered mutation (66)
      • engineered mutation (68)
      • engineered mutation (90)
      • engineered mutation (129)
      • engineered mutation (168)
      • engineered mutation (202)
      • expression tag (257-259)
    Domains in SCOPe 2.07: d7jo3a1, d7jo3a2
  • Heterogens: VGS, ZN, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >7jo3A (A:)
mshhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslril
nnghsfqvtfddsqdkavlkggpldgtyrllqfhfhwgsldgqgsehtvdkkkyaaelhl
vhwntkygdvgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktegksadftnfdp
rgllpesldywtypgslttpplaecvtwivlkepisvsseqvlkfrklnfngegepeelm
vdnwrpaqplknrqikasfk

    Sequence, based on observed residues (ATOM records): (download) 
    >7jo3A (A:)
hwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnng
hsfqvtfddsqdkavlkggpldgtyrllqfhfhwgsldgqgsehtvdkkkyaaelhlvhw
ntkygdvgkavqqpdglavlgiflkvgsakpglqkvvdvldsiktegksadftnfdprgl
lpesldywtypgslttpplaecvtwivlkepisvsseqvlkfrklnfngegepeelmvdn
wrpaqplknrqikasfk