PDB entry 7jk7

View 7jk7 on RCSB PDB site
Description: Crystal structure of Importin alpha 2 in complex with LSD1 NLS S111E mutant
Class: protein transport
Keywords: Importin alpha demethylase nuclear localisation, PROTEIN TRANSPORT
Deposited on 2020-07-27, released 2020-08-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: XRAY
Resolution: 1.96 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine-specific histone demethylase 1A
    Species: Homo sapiens [TaxId:9606]
    Gene: KDM1A, AOF2, KDM1, KIAA0601, LSD1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60341
      • engineered mutation (7)
  • Chain 'B':
    Compound: Importin subunit alpha-1
    Species: Mus musculus [TaxId:10090]
    Gene: Kpna2, Rch1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7jk7b_
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7jk7B (B:)
splqenrnnqgtvnwsvedivkginsnnlesqlqatqaarkllsrekqppidniiragli
pkfvsflgktdcspiqfesawaltniasgtseqtkavvdggaipafisllasphahiseq
avwalgniagdgsafrdlvikhgaidpllallavpdlstlacgylrnltwtlsnlcrnkn
pappldaveqilptlvrllhhndpevladscwaisyltdgpneriemvvkkgvvpqlvkl
lgatelpivtpalraignivtgtdeqtqkvidagalavfpslltnpktniqkeatwtmsn
itagrqdqiqqvvnhglvpflvgvlskadfktqkeaawaitnytsggtveqivylvhcgi
ieplmnllsakdtkiiqvildaisnifqaaeklgeteklsimieecggldkiealqrhen
esvykaslnliekyfsveeeedqnvvpettsegfafqvqdgapgtfnfgs

    Sequence, based on observed residues (ATOM records): (download) 
    >7jk7B (B:)
gtvnwsvedivkginsnnlesqlqatqaarkllsrekqppidniiraglipkfvsflgkt
dcspiqfesawaltniasgtseqtkavvdggaipafisllasphahiseqavwalgniag
dgsafrdlvikhgaidpllallavpdlstlacgylrnltwtlsnlcrnknpappldaveq
ilptlvrllhhndpevladscwaisyltdgpneriemvvkkgvvpqlvkllgatelpivt
palraignivtgtdeqtqkvidagalavfpslltnpktniqkeatwtmsnitagrqdqiq
qvvnhglvpflvgvlskadfktqkeaawaitnytsggtveqivylvhcgiieplmnllsa
kdtkiiqvildaisnifqaaeklgeteklsimieecggldkiealqrhenesvykaslnl
iekyf