PDB entry 7bhw
View 7bhw on RCSB PDB site
Description: Crystal structure of MAT2a bound to allosteric inhibitor (compound 29)
Class: transferase
Keywords: allosteric inhibitor, fragment-based drug design, synthetic lethal therapy, oncology, TRANSFERASE
Deposited on
2021-01-11, released
2021-04-21
The last revision prior to the SCOPe 2.07 freeze date was dated
2021-05-05, with a file datestamp of
2021-04-30.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: N/A
AEROSPACI score: 0.79
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: S-adenosylmethionine synthase isoform type-2
Species: Homo sapiens [TaxId:9606]
Gene: MAT2A, AMS2, MATA2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d7bhwa1, d7bhwa2, d7bhwa3 - Heterogens: TNW, SAM, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>7bhwA (A:)
qsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
Sequence, based on observed residues (ATOM records): (download)
>7bhwA (A:)
gtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsra
avdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagdq
glmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgav
lpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggp
qgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvl
vqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrta
ayghfgrdsfpwevpkklky