PDB entry 7bhw

View 7bhw on RCSB PDB site
Description: Crystal structure of MAT2a bound to allosteric inhibitor (compound 29)
Class: transferase
Keywords: allosteric inhibitor, fragment-based drug design, synthetic lethal therapy, oncology, TRANSFERASE
Deposited on 2021-01-11, released 2021-04-21
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-05-05, with a file datestamp of 2021-04-30.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: N/A
AEROSPACI score: 0.79 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-adenosylmethionine synthase isoform type-2
    Species: Homo sapiens [TaxId:9606]
    Gene: MAT2A, AMS2, MATA2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d7bhwa1, d7bhwa2, d7bhwa3
  • Heterogens: TNW, SAM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >7bhwA (A:)
    qsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
    vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
    qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
    dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
    dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
    rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
    vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
    

    Sequence, based on observed residues (ATOM records): (download)
    >7bhwA (A:)
    gtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsra
    avdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagdq
    glmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgav
    lpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggp
    qgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvl
    vqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrta
    ayghfgrdsfpwevpkklky