PDB entry 7bhu
View 7bhu on RCSB PDB site
Description: Crystal structure of MAT2a with elaborated fragment 26 bound in the allosteric site
Class: transferase
Keywords: allosteric inhibitor, fragment-based drug design, synthetic lethal therapy, oncology, TRANSFERASE
Deposited on
2021-01-11, released
2021-04-21
The last revision prior to the SCOPe 2.07 freeze date was dated
2021-05-05, with a file datestamp of
2021-04-30.
Experiment type: XRAY
Resolution: 1.15 Å
R-factor: N/A
AEROSPACI score: 0.77
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: S-adenosylmethionine synthase isoform type-2
Species: Homo sapiens [TaxId:9606]
Gene: MAT2A, AMS2, MATA2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d7bhua1, d7bhua2, d7bhua3 - Heterogens: TOW, SAM, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>7bhuA (A:)
qsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
Sequence, based on observed residues (ATOM records): (download)
>7bhuA (A:)
gtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsra
avdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagdq
glmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgav
lpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggp
qgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvl
vqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrta
ayghfgrdsfpwevpkklky