PDB entry 7bhr
View 7bhr on RCSB PDB site
Description: Crystal structure of MAT2a with triazinone fragment 1 bound in the allosteric site
Class: transferase
Keywords: allosteric inhibitor, fragment-based drug design, synthetic lethal therapy, oncology, TRANSFERASE
Deposited on
2021-01-11, released
2021-04-21
The last revision prior to the SCOPe 2.07 freeze date was dated
2021-05-05, with a file datestamp of
2021-04-30.
Experiment type: XRAY
Resolution: 1.08 Å
R-factor: N/A
AEROSPACI score: 0.83
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: S-adenosylmethionine synthase isoform type-2
Species: Homo sapiens [TaxId:9606]
Gene: MAT2A, AMS2, MATA2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d7bhra1, d7bhra2, d7bhra3 - Heterogens: TQE, SAM, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>7bhrA (A:)
qsmngqlngfheafieegtflftsesvgeghpdkicdqisdavldahlqqdpdakvacet
vaktgmillageitsraavdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdia
qgvhldrneedigagdqglmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrp
dsktqvtvqymqdrgavlpirvhtivisvqhdeevcldemrdalkekvikavvpakylde
dtiyhlqpsgrfviggpqgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaa
rwvakslvkgglcrrvlvqvsyaigvshplsisifhygtsqkserelleivkknfdlrpg
vivrdldlkkpiyqrtaayghfgrdsfpwevpkklky
Sequence, based on observed residues (ATOM records): (download)
>7bhrA (A:)
gtflftsesvgeghpdkicdqisdavldahlqqdpdakvacetvaktgmillageitsra
avdyqkvvreavkhigyddsskgfdyktcnvlvaleqqspdiaqgvhldrneedigagdq
glmfgyatdeteecmpltivlahklnaklaelrrngtlpwlrpdsktqvtvqymqdrgav
lpirvhtivisvqhdeevcldemrdalkekvikavvpakyldedtiyhlqpsgrfviggp
qgdagltgrkiivdtyggwgahgggafsgkdytkvdrsaayaarwvakslvkgglcrrvl
vqvsyaigvshplsisifhygtsqkserelleivkknfdlrpgvivrdldlkkpiyqrta
ayghfgrdsfpwevpkklky