PDB entry 7b7r

View 7b7r on RCSB PDB site
Description: MEK1 in complex with compound 4
Class: transferase
Keywords: Kinase, allosteric, fragments, TRANSFERASE
Deposited on 2020-12-11, released 2021-03-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2021-03-03, with a file datestamp of 2021-02-26.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02750 (17-243)
      • expression tag (13-16)
    • Uniprot Q02750 (250-End)
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02750 (Start-243)
      • linker (249)
      • linker (244-246)
    • Uniprot Q02750 (250-End)
    Domains in SCOPe 2.07: d7b7rb_
  • Heterogens: T1K, ANP, MG, SO4, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >7b7rB (B:)
mahhhhhhaaaenlyfqleeleldeqqrkrleafltqkqkvgelkdddfekiselgagng
gvvfkvshkpsglvmarklihleikpairnqiirelqvlhecnspyivgfygafysdgei
sicmehmdggsldqvlkkagripeqilgkvsiavikgltylrekhkimhrdvkpsnilvn
srgeiklcdfgvsgqlidsmansfvgtrsymsperlqgthysvqsdiwsmglslvemavg
rypigsgsgsmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmv
hafikrsdaeevdfagwlcstiglnq

    Sequence, based on observed residues (ATOM records): (download) 
    >7b7rB (B:)
eleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmarkl
ihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkka
gripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlids
matrsymsperlqgthysvqsdiwsmglslvemavgrypigsgsmaifelldyivneppp
klpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigln