PDB entry 6zci

View 6zci on RCSB PDB site
Description: Crystal structure of BRD4-BD1 in complex with NVS-BET-1
Class: transcription
Keywords: chromatin binding, bromodomain, acetylated histone binding, transcription regulation, TRANSCRIPTION
Deposited on 2020-06-11, released 2020-12-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-12-23, with a file datestamp of 2020-12-18.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (23-End)
      • expression tag (21-22)
    Domains in SCOPe 2.07: d6zcia1, d6zcia2
  • Heterogens: QFN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6zciA (A:)
mhhhhhhssgvdlgtenlyfqsmnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfa
wpfqqpvdavklnlpdyykiiktpmdmgtikkrlennyywnaqeciqdfntmftncyiyn
kpgddivlmaealeklflqkinelptee

    Sequence, based on observed residues (ATOM records): (download) 
    >6zciA (A:)
smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
nelpte