PDB entry 6ycu

View 6ycu on RCSB PDB site
Description: Fragment KCL_K777 in complex with MAP kinase p38-alpha
Class: transferase
Keywords: fbdd, fragment based drug design, p38, mapk14, kinase, transferase
Deposited on 2020-03-19, released 2020-04-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-04-08, with a file datestamp of 2020-04-03.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 14
    Species: Mus musculus [TaxId:10090]
    Gene: Mapk14, Crk1, Csbp1, Csbp2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P47811
      • engineered mutation (161)
    Domains in SCOPe 2.07: d6ycua_
  • Heterogens: OKZ, SB4, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ycuA (A:)
msqerptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfq
siihakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcq
kltddhvqfliyqilrglkyihsadiihrdlkpsnlavnedselkildfglarhtddemt
gyvatrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvg
tpgaellkkissesarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaa
qalahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppldqeemes

    Sequence, based on observed residues (ATOM records): (download) 
    >6ycuA (A:)
ptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktghrvavkklsrpfqsiiha
krtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltdd
hvqfliyqilrglkyihsadiihrdlkpsnlavnedselkildfarhtdyvatrwyrape
imlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaellkkiss
esarnyiqslaqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahayfaqyh
dpddepvadpydqsfesrdllidewksltydevisfvpppldqeeme